Mechanism of action of AURYXIA
Watch this video and learn how the unique formulation of AURYXIA works in the body to help manage adult patients’ phosphorus levels.1,2
Chronic kidney disease, CKD, is characterized by a gradual loss of kidney function.3 The kidneys play an important role in regulating the amount of phosphorus in blood, removing excess phosphorus for renal excretion.3,4 Loss of kidney function in end stage renal disease diminishes the kidney’s ability to control serum phosphate levels, causing hyperphosphatemia.4
AURYXIA is a unique formulation of ferric citrate coordination complexes indicated for the control of serum phosphorus levels in adults with CKD receiving dialysis.1,2,5 AURYXIA is an iron-based, calcium-free, non-chewable phosphate binder, which after swallowing reaches the gastrointestinal tract where ferric iron binds to dietary phosphates to produce ferric phosphate, an insoluble compound that is readily excreted in fecal matter.1,2,6-8 By lowering gastrointestinal phosphate absorption, AURYXIA reduces serum phosphorus concentrations in patients with CKD receiving dialysis.1,2,6-8
How AURYXIA lowers phosphate levels
AURYXIA is a unique formulation of ferric citrate coordination complexes for control of serum phosphorus levels in adults with CKD receiving dialysis.1,2,5
Ferric iron binds to dietary phosphate in the GI tract to produce ferric phosphate1
This compound is insoluble and is readily excreted in the stool1
By lowering gastrointestinal phosphate absorption, AURYXIA reduces serum phosphorus concentrations1
CKD=chronic kidney disease.
See how AURYXIA helped patients reach their target goals
AURYXIA helped patients reach and stay in the range of 3.5-5.5 mg/dL during a 56-week trial.1
Patients had a mean serum phosphorus level of 7.41 mg/dL at baseline and 4.88 mg/dL at Week 56.9
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A multicenter, randomized, open‐label trial evaluated the ability of AURYXIA to lower serum phosphorus in patients with CKD on dialysis over 56 weeks. Eligible patients had serum ferritin <1000 ng/mL, serum TSAT <50%, and serum phosphorus ≥2.5 and ≤8.0 mg/dL at the screening visit. The safety and efficacy of AURYXIA were studied in the 52‐week active‐controlled period (AURYXIA n=292, Active Control n=149), then AURYXIA patients were re‐randomized to either continue AURYXIA treatment or receive placebo during the placebo‐controlled period, weeks 52‐56 (AURYXIA n=96, placebo n=96). The primary endpoint was the change in serum phosphorus from baseline (Week 52) to Week 56 between AURYXIA and placebo. The key secondary endpoint was the change in serum phosphorus from baseline (Week 0) to Week 52 between AURYXIA and Active Control.
TSAT=transferrin saturation; Active Control=sevelamer carbonate and/or calcium acetate.